Antithyroid activity of some 6-(alkylsulfanyl)-9H-purines
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چکیده
منابع مشابه
Antithyroid activity of some 6-(alkylsulfanyl)-9H-purines
Some alkyl and aryl derivatives of 9H-purine-6-thiol were synthesized and evaluated in vitro and in vivo for potential antithyroid effects. Spectrophotometric studies demonstrated 1:1 charge transfer complexation between iodine and these compounds with quite high values of the formation constants. The blood assays of rats treated with these compounds revealed significant antithyroid activity fo...
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A atividade antitireóidea do 6-cloropurina, in vitro, foi determinada espectrofotometricamente por estudos de formação de seu complexo com iodo. O complexo mostrou estequiometria de 1:1. A constante de formação do complexo encontrada foi 7,652 × 10 L mol, o que indicou um bom potencial de 6-cloropurina, como agente antitireóideo. Posteriores verificações mostraram mudanças nos níveis hormonais ...
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Some novel as well as known derivatives of 8-sulfanyl-3,9dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentratio...
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Twenty-one samples of water were collected from commercial egg production farms in Georgia with or without a history of fatty liver syndrome. These samples plus a sample of water from the University of Georgia Poultry Farm were analyzed for various mineral elements by atomic absorption, direct reading emission spectroscopy and by neutron activation. Water samples from farms with a history of fa...
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ژورنال
عنوان ژورنال: Journal of the Serbian Chemical Society
سال: 2011
ISSN: 0352-5139,1820-7421
DOI: 10.2298/jsc101209041i